From pack trails and wagon roads that marked this area at least 300 years have developed such modern roads as U.S. Highway 181. The old trails of Indians, wild cattle and Mustang horses formed highways for 17th, 18th and 19th century expeditions coming from Mexico to claim sovereignty for Spain over land in Texas. When pioneers established land grants in this section, they also found Indian trails useful, placing towns along them. Beeville, the county seat, was situated at the natural intersection of San Patricio-Helena Road with Goliad-Laredo Road.
  About 20 miles south, the Matamoros-Goliad Road (Camino Real to old-timers) was probably the most historic road in this area. In the years 1861- 1865 the "Cotton Road" called "lifeline of the Southern Confederacy" - crossed Bee County. A later route of great value was a cattle trail that channeled thousands of Longhorns north from the Rio Grande to the Red River and up the Dodge City Trail of the Chisholm Trail to northern markets. In this area were also La Para (or grapevine) Road, the lndianola- Papalote Road, and a road to now-vanished Saint Mary's, a port on Copano Bay, off the Gulf of Mexico.